منابع مشابه
Cancer imaging with radiolabelled antibodies and peptides.
Radiology requires a mass of tissue, displacing tissue, infiltrating tissue, for contrast. Nuclear Medicine does not require a mass. It exploits the subtle differences between the cancer cell and the normal cell for identification. There is also an amplification factor. For example, antigen expression may be 500–50,000 per cell and receptor expression may be between 500 and 10,000 per cell. The...
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Imaging techniques allowing non-invasive monitoring of tumour angiogenesis have attracted great interest over the last years. The integrin alpha(v)beta3 is overexpressed during tumour spread and metastasis and therefore is an attractive target for monitoring angiogenetic processes. This review summarizes attempts to develop radiolabelled peptides based on the Arg-Gly-Asp (RGD) sequence and rela...
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Cationic antimicrobial peptides are produced by almost all species of life as a component of their immediate non-specific defense against infections. The assets of these peptides in clinical application include their potential for broad-spectrum activity, rapid bactericidal activity and low propensity for resistance development, whereas possible disadvantages include their high cost, limited st...
متن کاملBioactive Peptides in Cancer: Therapeutic Use and Delivery Strategies
Human cancer is one of the most important causes of death in western and industrialized countries. In advanced stages, therapeutic opportunities are still limited due to the difficulty to target specifically only cancer cells sparing healthy ones. Cancer often has specific molecular alterations of signal transduction pathway or of other molecules linked to the proliferation and wide spreading o...
متن کاملTherapeutic Potentials of Antimicrobial Peptides
Volume 5 • Issue 3 • 2013 Antimicrobial peptides (AMPs) are small proteins (<100 amino acids) which include alpha-defensins, beta-defensins and the cathelicidin LL-37 in humans [1]. Alpha-defensins are expressed in neutrophils as part of their non-oxidative antimicrobial mechanismsand are also found in Paneth cells in the intestine [2,3]. They are synthesized as precursors that are proteolytica...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2000
ISSN: 0923-7534
DOI: 10.1093/annonc/11.suppl_3.267